Thermo Fisher Scientific Collaborates with TransMIT GmbH on High-Performance Orbitrap Mass Spectrometry Imaging Platform


Co-marketing agreement between Thermo Fisher Scientific and TransMIT enables high spatial resolution, high mass MSI platform to study complex biological tissues

Thermo Fisher Scientific Inc. and TransMIT GmbH Center for Mass Spectrometric Developments announced a co-marketing agreement to promote the use of a mass spectrometry imaging (MSI) platform for spatial multi-omics applications in laboratories pharmaceutical and clinical.

In this relationship, TransMIT will combine its proprietary scanning microprobe Matrix-Assisted Laser Desorption/Ionization (SMALDI) MSI technology and the exceptional High Resolution Accurate Mass (HRAM) power of Thermo Scientific Orbitrap MS instrumentation. TransMIT’s AP-SMALDI⁵ AF ion source coupled with Orbitrap MS technology enables the mapping of the spatial distribution of a variety of molecules such as biomarkers, metabolites, peptides or enzymatically digested proteins by their masses molecular. This approach can be applied to omics applications such as metabolomics, lipidomics, proteomics, glycomics, and pharmacokinetic studies in a variety of tissues.

“This co-marketing agreement will provide integrated solutions for mass spectrometry imaging, offering a label-free approach to mapping the distribution of a wide range of known and unknown compounds directly sampled from biological tissues,” said Jim Yano, Senior Director, Life Sciences Mass Spectrometry, Chromatography and Mass Spectrometry Portfolio Management, Thermo Fisher Scientific. “Due to its high spatial resolution performance, TransMIT’s AP-SMALDI⁵ AF ion source is ideally suited for the high mass resolution and precise mass capabilities of Orbitrap MS instrumentation.”

Professor Bernhard Spengler, Director of the TransMIT Center for Mass Spectrometric Developments, said: “Our AF AP-SMALDI⁵ ion source combined with Thermo Fisher’s Orbitrap technology creates an MSI platform for high spatial resolution as well as high resolution and mass accuracy. The AP-SMALDI-Orbitrap configuration enables scanning of tissue samples or 3D objects with the pulsed laser beam of 5 μm spot size routinely without oversampling, providing a powerful solution for drug development and spatial multi-omics applications.

The announcement of the new co-marketing agreement coincides with the 70th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Related Topics, to be held June 5-9, 2022, where Thermo Fisher will present its latest innovations at Booth 400 at the Minneapolis Convention Center, Minneapolis, Minnesota and the Hilton Minneapolis Grand Ballrooms E, F, G.

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